鐢�(ch菐n)鍝佺洰閷�
PCATALOGSPG鑶滄妧琛�(sh霉)锛氳壘淇℃纰艰垏鑹句俊绱嶇背绮掔浉绲�(ji茅)鍚�锛屽鐝�(xi脿n)楂橀潏鏁忓害澶氳矾寰�(f霉)鐢ㄦ娓�
鐧�(f膩)甯冿細2021-12-23銆�榛炴搳锛�1485
鍩轰簬鍏夊(xu茅)绶ㄧ⒓寰悆鐨勬嚫娴櫍鍒楁妧琛�(sh霉)鍦ㄥ熀鍥犲垎鏋愩�佽泲鐧借瓬鍒嗘瀽銆佹棭鏈熺柧鐥呰ê鏂�銆佹不鐧傜洠(ji膩n)娓瓑鏂归潰鐨勫璺娓彈鍒颁簡寤ｆ硾鐨勯棞(gu膩n)娉�銆備絾姊濈⒓鐨勭啋鍏夌┅(w臎n)瀹氭�у拰妾㈡脯闈堟晱搴︽湁寰呴�蹭竴姝ユ彁楂�锛屼互婊胯冻鏃ョ泭澧為暦鐨�“绮炬簴(zh菙n)瑷烘柗”闇�姹�銆�
鏂规硶:鏈伐浣滃牨閬撲簡涓�绋熀浜庢サ绌�(w臎n)瀹氱殑AIEgens(AIE33鍜孉IE NIR800)寰悆浣滅偤姊濆舰纰�锛�AIEgens1,1,2,3,4,5-鍏嫰鍩�- 1h -silole, HPS)寰悆浣滅偤鐔掑厜淇¤櫉鍫卞憡鍣紝骞剁祼(ji茅)鍚堟祦寮忕窗(x矛)鑳炲剙閫茶澶氳矾妾㈡脯鐨勬柊鍨嬫嚫娴櫍鍒楀钩鑷�銆�
绲�(ji茅)鏋�:鐢变簬HPS绱嶇背绮掑叿鏈夎壇濂界殑鐔掑厜淇¤櫉鏀惧ぇ鏁堟噳(y墨ng)锛岃垏QDs绱嶇背绮�(鎻愰珮3鍊�)鍜屽晢妤�(y猫)鏈夋鏌撴枡钘荤磪铔嬬櫧(鎻愰珮5鍊�)浣滅偤鐔掑厜淇¤櫉鍫卞憡鐗╃殑澶氶噸妾㈡脯鏂规硶鐩告瘮锛屾垜鍊戠殑澶氶噸妾㈡脯鏂规硶鍏锋湁鏇撮珮鐨勬娓潏鏁忓害銆�
绲�(ji茅)璜�:姝ゅ锛岄璀夊椹楅’绀�锛屽湪鎮ｈ�呰娓呮ǎ鏈腑妾㈡脯閬庢晱鍘熺殑鑷ㄥ簥閲戞(bi膩o)婧�(zh菙n)鏂规硶鑸嘔mmunoCAP鐩镐技锛岃┎鎳告诞闄ｅ垪骞宠嚭鍏锋湁鑹ソ鐨勭啋鍏夌┅(w臎n)瀹氭�у拰杓冨挤鐨勪俊铏熸斁澶ц兘鍔�锛屽叿鏈夐珮闈堟晱搴﹀璺敓鐗╂娓殑鎳�(y墨ng)鐢ㄥ墠鏅�銆�
闂�(gu膩n)閸佃:鑱氶泦瑾樺皫(d菐o)鎺掓斁; AIEgens姊濆舰纰�;AIEgens绱嶇背绮�;澶氳矾妾㈡脯閬庢晱鍘�
浠嬬垂锛�
鍒╃敤鍏夊(xu茅)绶ㄧ⒓寰悆鐨勬嚫娴櫍鍒楀湪楂橀�氶噺澶氳矾妾㈡脯涓櫦(f膩)鎻簡绐佸嚭鐨勪綔鐢�锛岀敱浜庡叾蹇�熺祼(ji茅)鍚堝嫊鍔涘(xu茅)銆侀珮閫氶噺澶氳矾妾㈡脯鍜岄珮妾㈡脯闈堟晱搴︼紝鏄熀鍥犲垎鏋�銆佽泲鐧借瓬鍒嗘瀽銆佹棭鏈熺柧鐥呰ê鏂峰拰娌荤檪鐩�(ji膩n)娓殑寮峰ぇ宸ュ叿銆�鐔掑厜绶ㄧ⒓寰悆閫氬父琚敤浣滃浐楂旇級楂斿拰璺熻工纰�锛屼互瀵︾従(xi脿n)灏嶅鍊嬬洰妯�(bi膩o)鐨勫苟琛屾娓紝鏄嚫娴櫍鍒椾腑浣跨敤鐨勪富瑕佹妧琛�(sh霉)涔嬩竴銆傜啋鍏夌法纰煎井鐞冪殑鐞嗘兂鎬ц兘鏄法纰煎閲忓ぇ銆佸潎鍕绘�уソ銆佺啋鍏夌┅(w臎n)瀹氭�ч珮銆傞珮妾㈡脯闈堟晱搴﹀皪浜庝綆婵冨害铔嬬櫧鎴栧叾浠栫敓鐗╁垎瀛愬皪鐤剧梾鐨勬棭鏈熸簴(zh菙n)纰鸿ê鏂蜂篃闈炲父閲嶈銆傞洊鐒剁洰鍓嶇殑鎳告灦闄ｅ垪鎶�琛�(sh霉)姣斿偝绲�(t菕ng)鐨勬娓钩鑷哄叿鏈夋洿楂樼殑妾㈡脯闈堟晱搴�锛屼絾闈堟晱搴﹂倓闇�瑕侀�蹭竴姝ユ彁楂�锛屼互婊胯冻“绮炬簴(zh菙n)瑷烘柗”鏃ョ泭澧為暦鐨勯渶姹�銆�
绲�(ji茅)璜�
缍滀笂鎵�杩帮紝鎴戝�戦娆″皣AIEgens寮曞叆鍒版嚫娴櫍鍒椾腑锛屽苟鎴愬姛妲�(g貌u)寤轰簡涓�绋熀浜嶢IEgens寰彔浣滅偤姊濆舰纰笺�丄IEgens绱嶇背绮掍綔鐐虹啋鍏変俊铏熷牨鍛婂櫒銆佸柈婵�鍏夋縺鐧�(f膩)娴佸紡绱�(x矛)鑳炲剙閫茶澶氳矾妾㈡脯鐨勬柊鍨嬫嚫娴櫍鍒楀钩鑷�銆傛垜鍊戝埄鐢ㄧ啊鏄撶殑Shirasu澶氬瓟鐜荤拑(SPG)鑶滀钩鍖栨柟娉曪紝閫氶亷绨″柈鍦版敼璁奡PG鑶滅殑瀛斿緫锛屽悎鎴愪簡AIEgens姊濆舰纰煎拰AIEgens绱嶇背绮掋�傚埗鍌欑殑寰悆绮掑緫鍒嗗竷绐�锛岀啋鍏夊潎鍕绘�уソ锛岀啋鍏夌┅(w臎n)瀹氭�уソ銆傚畠鍊戠殑鐔掑厜寮峰害涔熼潪甯哥┅(w臎n)瀹�锛屽嵆浣垮湪楂橀吀鎬у拰楂樺牽鎬х殑婧舵恫涓�锛岃瓑鏄庝簡鍦ㄥ牨閬撶殑鍏夊(xu茅)绶ㄧ⒓鐝犱腑鍏锋湁鍎�(y艒u)瓒婄殑鐔掑厜绌�(w臎n)瀹氭��銆傛垜鍊戦�氶亷鏀硅畩AIEgens (HPS, AIE41, AIE33鍜孉IE NIR800)鐨勭櫦(f膩)灏勬尝闀峰拰鐧�(f膩)鍏夊挤搴︽按骞�锛屾垚鍔熷湴鍒朵綔浜嗕竴鍊嬪寘鍚�30鍊嬪熀浜�“鍠尝闀�”绶ㄧ⒓鏂规硶鐨勪簩缍瑼IEgens姊濆舰纰煎韩銆傛澶�锛屾垜鍊戝皣AIE33鍜孉IE NIR800寰彔姊濆舰纰煎拰HPS寰彔鐔掑厜淇¤櫉鍫卞憡鍎�绲�(ji茅)鍚堝湪娴佸紡绱�(x矛)鑳炲剙涓婃娓柈涓�妯ｆ湰涓�5绋父瑕嬬殑閬庢晱鍘�銆備娇鐢ˋIEgens绱嶇背绮掍綔鐐虹啋鍏変俊铏熷牨鍛婂櫒鐨勫閲嶆娓柟娉曡垏浣跨敤鍟嗘キ(y猫)鍖栫殑钘荤磪铔嬬櫧鏈夋妯�(bi膩o)绨�(鎻愰珮5鍊�)鍜孮Ds绱嶇背绮�(鎻愰珮3鍊�)浣滅偤鍫卞憡鍣ㄧ殑澶氶噸妾㈡脯鏂规硶鐩告瘮锛屽叿鏈夋洿楂樼殑妾㈡脯闈堟晱搴︺�傝〃鏄嶩PS绱嶇背绮掑叿鏈夎壇濂界殑鐔掑厜淇¤櫉鏀惧ぇ鏁堟噳(y墨ng)銆傞�氶亷妾㈡脯95渚嬫偅鑰呮ǎ鏈嵅寰楃殑绲�(ji茅)鏋滆〃鏄�锛岃垏鐩墠鐨勮嚚搴婂厤鐤玞ap閲戞(bi膩o)婧�(zh菙n)鏂规硶鐩告瘮锛屾瘡绋亷鏁忓師鍦ㄩ潏鏁忓害鍜岀壒鐣版�ф柟闈㈤兘瀵︾従(xi脿n)浜嗛浼肩殑妾㈡脯鐗规��銆傜祼(ji茅)鏋滆〃鏄�锛屽熀浜庡叿鏈夊劒(y艒u)鐣扮啋鍏夌┅(w臎n)瀹氭�х殑AIEgens寰悆鍜屽叿鏈夎純寮蜂俊铏熸斁澶ц兘鍔涚殑AIEgens绱嶇背鐞冪殑鎳告诞闄ｅ垪骞宠嚭鍏锋湁鑹ソ鐨勭敓鐗╂噳(y墨ng)鐢ㄥ墠鏅�锛屾湭渚嗗彲鎳�(y墨ng)鐢ㄤ簬鍏朵粬铔嬬櫧璩�(zh矛)銆佹牳閰稿拰绱�(x矛)鑳炲洜瀛�銆�
