鐢�(ch菐n)鍝佺洰閷�
PCATALOG绶╅噵寰悆鐨勫埗鍌欐柟娉�
鐧�(f膩)甯冿細2021-07-05銆�榛�(di菐n)鎿婏細1970
绶╅噵寰悆鏄寚钘ョ墿婧惰В鎴栧垎鏁ｅ湪楂樺垎瀛愭潗鏂欏熀璩�(zh矛)涓舰鎴愮殑绮掑緫灏哄澶у皬鍒嗗竷鍦� 5锝�250 μm 涔嬮枔鐨勭悆鐙�瀵�(sh铆)楂�锛�鍒╃敤绶╅噵寰悆闁�(k膩i)鐧�(f膩)鏂板瀷鐨勭郸钘ョ郴绲�(t菕ng)閫愭几鎴愮偤绉戝(xu茅)鐣屽強宸ユキ(y猫)鐣岄棞(gu膩n)娉ㄧ殑鐒﹂粸(di菐n)锛�鐞嗘兂鐨勭珐閲嬪井鐞冨埗鍔戠殑鎬ц唱(zh矛)鐢辨椿鎬х墿璩�(zh矛)銆佷钩鍖栨妧琛�(sh霉)浠ュ強鑱氬悎鐗╂潗鏂欎笁鑰呭叡鍚屾焙瀹氥�傚井鐞冪殑鍒跺倷闂�(gu膩n)閸靛湪浜庝笉鍍呰淇濇寔钘ョ墿鍘熸湁鐨勬椿鎬�锛岄倓闇�瑕佽棩鐗╁寘灏佺巼楂�銆佸井鐞冪矑寰戝潎涓�銆佸埗鍌欏伐钘濋噸寰�(f霉)鎬уソ锛�鍥犳鍦ㄥ埗鍌欏井鐞冩檪(sh铆)锛屼笉鍍呰闈炲父浜嗚В钘ョ墿鑷韩鐨勭悊鍖栨�ц唱(zh矛)锛岄倓瑕侀潪甯哥啛鎮夊父鐢ㄨ紨鏂欑殑鎬ц唱(zh矛)鍙婁钩鍖栧伐钘濇妧琛�(sh霉)銆�鏈枃瑭崇窗(x矛)浠嬬垂浜嗗父瑕�(ji脿n)骞剧ó绶╅噵寰悆鐨勫埗鍌欐柟娉曞拰灏�(du矛)鎳�(y墨ng)鐨勫伐钘濊ō(sh猫)鍌�銆�
1銆佺珐閲嬪井鐞冨埗鍔戠殑鏉愭枡閬告搰
鐩墠寰悆鍒跺姂鏉愭枡鍙ぇ楂斿垎鐐哄叐椤�(l猫i):澶╃劧渚�(l谩i)婧愮殑鑱氬悎鐗╁拰浜哄伐鍖栧(xu茅)鍚堟垚鐨勮仛鍚堢墿銆傚ぉ鐒朵締(l谩i)婧愮殑鑱氬悎鐗╁児(ji脿)鏍间綆寤変笖渚�(l谩i)婧愬唬娉�锛屽彲鍒嗙偤澶氱硸鍜岃泲鐧借唱(zh矛)椤�(l猫i)绛夛紝濡傝憽鑱氱硸銆佹鑱氱硸銆佹捣钘婚吀楣�銆佹穩绮�銆佹槑鑶犮�佺櫧铔嬬櫧绛�锛�澶╃劧渚�(l谩i)婧愮殑鑱氬悎鐗╁皪(du矛)绱斿寲鏈夎憲杓冮珮鐨勮姹傦紝鐣�(d膩ng)浣滅偤寰悆杓旀枡鐢ㄤ簬澶ф壒閲忕敓鐢�(ch菐n)鏅�(sh铆)杓冮洠淇濇寔鎵规闁撳毚(y谩n)鏍肩殑璩�(zh矛)閲忔(bi膩o)婧�(zh菙n)銆傚父鐢ㄧ殑鍖栧(xu茅)鍚堟垚鑱氬悎鐗╁彲鍒嗙偤鑱氶叝銆佽仛閰搁厫銆佽仛纾疯厛銆佽仛閰拌兒銆佽仛纾烽吀閰瓑锛�鍏跺劒(y艒u)榛�(di菐n)鏄彲浠ラ�氶亷(gu貌)浜虹偤鎺у埗鑱氬悎鍒跺倷宸ヨ棟锛屼締(l谩i)淇濊瓑钘ョ敤杓旀枡绱�(j铆)鍒ョ殑璩�(zh矛)閲�锛�鐣�(d膩ng)浣滅偤杓夎棩寰悆鐨勯鏋舵潗鏂欐檪(sh铆)锛岃仛鍚堢墿鏉愭枡閭勫彲浠ラ�氶亷(gu貌)鏀硅畩榛忓害鍙婂垎瀛愰噺绛夊弮鏁�(sh霉)锛岄潏娲诲湴鎺у埗杓夎棩寰悆鐨勯檷瑙ｉ�熷害锛屼互瑾�(di脿o)绡�(ji茅)鎵�鍖呭煁钘ョ墿鐨勯噵鏀鹃�熺巼銆傚彟澶栧皪(du矛)鑱氬悎鐗╂潗鏂欐垨寰悆琛ㄩ潰閫�(j矛n)琛岀壒鐣版�т慨椋捐兘浣垮井鐞冨叿鏈変富鍕�(d貌ng)闈跺悜鎬�锛岀簿婧�(zh菙n)瀹氫綅鍒扮梾鐏跺崁(q奴)鍩熸垨鏀硅畩閲嬫斁琛岀偤锛�鍥犳鍖栧(xu茅)鍚堟垚鐨勮仛鍚堢墿鏄井鐞冪爺绌跺強鐢熺敘(ch菐n)鍘熸枡鐨勪富瑕佷締(l谩i)婧�銆�
2銆佸井鐞冪殑鍒跺倷鏂规硶
寰悆鐨勫埗鍌欐柟娉曞緢澶�锛屽父鐢ㄧ殑鏈変钩鍖�—婧跺姂鎻櫦(f膩)娉曘�佸櫞闇у共鐕ユ硶銆佺浉鍒嗛洟娉�銆佽秴鑷ㄧ晫娴侀珨娌夌⿳娉曞拰鐔辩啍鎿犲嚭鐮旂（娉曠瓑锛屽彲鏍规摎(j霉)钘ョ墿鐨勬�ц唱(zh矛)銆佸埗鍌欏井鐞冪殑鐩殑閬告搰鍚堥仼鐨勬柟娉曘��
2.1涔冲寲婧跺姂鎻櫦(f膩)娉�
浣跨敤 PLGA 浣滅偤杓夐珨鍒跺倷寰悆锛屼钩鍖�—婧跺姂鎻櫦(f膩)鏂瑰紡鏄渶甯哥敤鐨�锛�涔冲寲婧跺姂鎻櫦(f膩)娉曞寘鎷柈涔虫硶鍜屽京(f霉)涔虫硶锛岄仼鐢ㄤ簬瑕剛鎬ц棩鐗�锛岀敤姘村寘娌癸紙O/W锛夋柟娉曢��(j矛n)琛屽埗鍌�锛屽叿楂旀柟娉�鈶�鏍规摎(j霉)钘ョ墿鐨勭墿鐞嗘�ц唱(zh矛)閬告搰鐩告噳(y墨ng)鐨� PLGA 淇＞鐨勬湯绔熀鍦�(tu谩n)锛�鈶�閬告搰鍚堥仼鍒嗗瓙閲忓ぇ灏忕殑 PLGA锛�鈶�閫氶亷(gu貌)鎺у埗 PLGA 鍒嗗瓙閲�锛屾憾鍔戠殑婵冨害鍙婄涓�鐩歌垏绗簩鐩哥殑姣斾緥鍙婃敧鎷岄�熺巼锛屾帶鍒跺埗鍌欑殑 PLGA 寰悆銆�
灏�(du矛)浜庝笉婧朵簬姘存垨姘存憾鎬ц純宸殑钘ョ墿閬╃敤鍠钩娉�锛屽叿楂旀柟娉曟槸灏囪棩鐗╂憾瑙ｆ垨娣锋嚫浜庨珮鍒嗗瓙婧舵恫鐣�(d膩ng)涓�锛岀劧鍚庡皣寰楀埌鐨勬贩鍚堢墿鍒嗘暎鍦ㄨ垏鍏朵笉鐩稿鐨勫惈鏈変钩鍖栧姂鐨勬按鐩镐腑锛屼笉鏂锋敧鎷�锛屼娇婧跺姂鎻櫦(f膩)锛屽緱鍒板浐楂斿井鐞�銆傚皪(du矛)浜庨洠婧朵簬鏈夋(j墨)婧跺姂鐨勬按婧舵�ц棩鐗╅仼鐢ㄥ京(f霉)涔虫硶锛屽叿楂旂殑鍒跺倷鏂规硶锛氾紙1锛夊皣钘ョ墿婧惰В浜庢按涓�锛涳紙2锛夊皣 PLGA 婧朵簬浜屾隘鐢茬兎绛夋湁姗�(j墨)婧跺姂锛涳紙3锛夊皣鍏╄�呴珮閫熸敧鎷屽悗寰楀埌鍒濅钩锛涳紙4锛夊皣鍒濅钩缃簬澶栨按鐩镐腑锛屽緱鍒板京(f霉)涔筹紙鍗� W/O/W 姘村寘娌瑰寘姘翠钩婵佹恫锛�銆�
鍒跺倷鐨勫伐钘濆拰瑷�(sh猫)鍌欙細娉曞湅(gu贸)VMI鍏徃鐨勫(sh铆)椹�(y脿n)瀹ゅ鍔熻兘鍧囪唱(zh矛)涔冲寲姗�(j墨)Turbotest鍙互閬搁厤澶氱ó涔冲寲鏀媽宸ュ叿锛岃檿鐞嗚兘鍔�200ml-20L锛屼钩鍖栭�熷害鑼冨湇50-3300RPM锛涘叾涓│鍜岀敓鐢�(ch菐n)瑕�(gu墨)妯′钩鍖栬ō(sh猫)鍌欑殑铏曠悊鑳藉姏寰�50L鍒�1500L鍙伕銆�
2.2鍣撮湩骞茬嚗娉�
鍣撮湩骞茬嚗娉曞埗鍌欏井鐞冪殑閬�(gu貌)绋嬫槸灏囨恫楂斿師鏂欏櫞闇у埌鐔卞共鐕ヤ粙璩�(zh矛)(绌烘埃銆佹垨鑰呮爱?d煤)?/font>)涓紝浣垮叾杞�(zhu菐n)璁婃垚骞茬矇鐨勯亷(gu貌)绋�锛屽ぇ楂斿彲鍒嗙偤涓�鍊�(g猫)姝ラ锛�鈶�閫氶亷(gu貌)闇у寲鍣ㄥ皣鍘熸枡闇у寲鎴愬皬娑叉淮锛�鈶�鍦ㄨ垏骞茬嚗姘ｉ珨鎺ヨЦ鏅�(sh铆)灏囨恫婊村共鐕�锛�鈶�灏囧共鐕ョ殑椤嗙矑寰炲共鐕ヤ粙璩�(zh矛)涓垎闆㈠嚭渚�(l谩i)銆傞亷(gu貌)绋嬩腑閫氶亷(gu貌)閬告搰涓嶅悓澶у皬鐨勫櫞鍢村拰瑾�(di脿o)鏁村(sh铆)椹�(y脿n)姊濅欢鍙互鍒跺倷涓嶅悓褰㈡厠(t脿i)鍜屽ぇ灏�鐨勫井鐞�銆�
鍣撮湩骞茬嚗鍒跺倷寰悆鎶�琛�(sh霉)鐨勫劒(y艒u)榛�(di菐n)锛�鈶�鍙敤浜庡埗鍌欏绋棩鐗╁井鐞�锛岀壒鍒ユ槸鍏锋湁鐢熺墿娲绘�х殑铔嬬櫧鍜屽鑲介(l猫i)钘ョ墿锛屽湪鍒跺倷閬�(gu貌)绋嬩腑锛屾椿鎬ф悕澶�??锛�鈶�鍒跺倷閬�(gu貌)绋嬩腑鐒�(w煤)澶栨按鐩哥殑钘ョ墿鎼嶅け锛屽彲閬�(d谩)鍒板緢楂樼殑鍖呭皝鐜�銆傜己榛�(di菐n)锛�鈶�鍒跺緱鐨勫井鐞冨彲鑳介粡闄勫湪鍣撮湩骞茬嚗鍣ㄧ殑鍏�(n猫i)閮�锛岄�犳垚鐗╂枡鎼嶅け锛�鈶�鍦ㄥ埗鍌欓亷(gu貌)绋嬩腑闇�瑕佺壒鍒ユ敞鎰忔韩搴︽帶鍒�锛屽共鐕ユ韩搴﹂亷(gu貌)楂樺鏄撲娇寰悆璁婂舰銆佽仛闆�銆侀�犳垚鐔辨晱鎰熸�ц棩鐗╁け鍘绘椿鎬�锛岃�屽共鐕ユ韩搴﹂亷(gu貌)浣庢檪(sh铆)婧跺姂娈樿純澶�锛屽皪(du矛)寰悆绮掑緫鐨勬帶鍒惰純宸�銆�
鍣撮湩骞茬嚗娉曞洜鎿嶄綔姣旇純绨�(ji菐n)鍠�銆佸寘灏佺巼楂�銆佸埗寰楀井鐞冪矑寰戝潎鍕�銆佷竴姝ユ垚鐞冪瓑鐗归粸(di菐n)锛屾笡灏戜簡浜虹偤鎿嶄綔鐨勮宸�锛岀啊(ji菐n)鍖栦簡閬�(gu貌)绋嬩腑鐨勬粎鑿屽伐钘�锛岄仼鍚堜簬宸ユキ(y猫)涓婂ぇ瑕�(gu墨)妯＄殑鏀惧ぇ鐢熺敘(ch菐n)锛屽湪寰悆鐢熺敘(ch菐n)鍒跺倷涓殑鎳�(y墨ng)鐢ㄤ篃瓒婁締(l谩i)瓒婂銆�
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2.3鐩稿垎闆㈡硶
鐩稿垎闆㈡硶涔�鎳�(y墨ng)鐢ㄥ唬娉�锛屽彲浠ュ皣涓嶅悓鐗规�х殑钘ョ墿鍖呭煁閫�(j矛n)寰悆銆傚湪杓夎棩寰悆鐨勫埗鍌欎腑锛屾噳(y墨ng)鐢ㄨ純鐐哄唬娉涚殑鏄憾鍔戯紞闈炴憾鍔戞硶锛屽師鐞嗘槸鍦ㄨ仛鍚堢墿鐨勬湁姗�(j墨)婧舵恫涓姞鍏ョ涓�绲勫垎渚�(l谩i)闄嶄綆鑱氬悎鐗╃殑婧惰В搴�锛屼竴鍊�(g猫)閲嶈鐨�鐗归粸(di菐n)鏄�瑭插伐钘濈敘(ch菐n)鐢熷叐鍊�(g猫)娑茬浉(鐩稿垎闆�)銆傚湪鏀媽涓嬪悜鑱氬悎鐗�-钘ョ墿-婧跺姂楂旂郴涓姞鍏ユ湁姗�(j墨)闈炴憾鍔�锛岃┎鏈夋(j墨)闈炴憾鍔戦�愭几鍦拌悆鍙栬仛鍚堢墿鐨�婧跺姂锛�绲�(ji茅)鏋滀娇鑱氬悎鐗╅��(j矛n)琛岀浉鍒嗛洟锛屽舰鎴愰潪甯歌粺鐨勮級钘ユ恫婊�(鍙互鐢ㄦ敧鎷岄�熺巼鎺у埗娑叉淮绮掑緫)锛�鐒跺悗灏囪┎绯荤当(t菕ng)杞�(zhu菐n)绉诲埌鍙︿竴绋湁姗�(j墨)闈炴憾鍔戜腑锛屼娇寰悆鍥哄寲浠ュ緱鍒版渶绲傜殑寰悆鐢�(ch菐n)鍝�銆�
鐩稿垎闆㈡硶鍒跺倷寰悆鍎�(y艒u)榛�(di菐n)锛�鈶�鍙渶瑕佹(bi膩o)婧�(zh菙n)甯歌(gu墨)瑷�(sh猫)鍌欏苟涓旀槗浜庡垎鎵规鍒跺倷锛屼笉闇�瑕佸湪瑷�(sh猫)鍌欎笂閫�(j矛n)琛屾槀璨寸殑鎶曡硣锛�鈶�灏�(du矛)浜庤Κ姘存�ц棩鐗╂垚鐞冩�уソ銆傜己榛�(di菐n)锛�鈶�鍒跺倷閬�(gu貌)绋嬩腑浣跨敤澶ч噺鏈夋(j墨)婧跺姂锛屾渶绲傜敘(ch菐n)鍝佷腑鏈夋(j墨)婧跺姂鐨勫幓闄ゆ瘮杓冨洶闆�锛�鈶�鐩稿垎闆㈠埗鍌欑殑寰悆瀹规槗鑱氶泦鎴愬湗(tu谩n)锛屽ぇ瑕�(gu墨)妯＄敓鐢�(ch菐n)鍥伴洠锛�鈶�鐩告瘮鍏朵粬鍒跺倷鏂规硶锛屽井鐞冨湪瑕剛鎬х殑纭寲鍔戜腑鍥哄寲锛岀枏姘存�у彲鑳芥洿寮�(qi谩ng)锛岄渶瑕佺壒鍒ラ棞(gu膩n)娉�鍒嗘暎鍔戞垨鑰呰〃闈㈡椿鎬у姂鐨勮檿鏂归枊(k膩i)鐧�(f膩)锛�鈶�鐒�(w煤)鑿屾帶鍒舵瘮杓冨洶闆ｃ��
鍒跺倷鐨勫伐钘濆拰瑷�(sh猫)鍌欙細娉曞湅(gu贸)VMI鍏徃鐨勫(sh铆)椹�(y脿n)瀹ゅ鍔熻兘鍧囪唱(zh矛)涔冲寲姗�(j墨)Turbotest閬告搰鍚堥仼鐨勬敧鎷屾伎寰堝鏄撳畬鎴�鐩稿垎闆㈡硶鐨勬敧鎷屽姛鑳�銆�
2.4瓒呰嚚鐣屾祦楂旀矇绌嶆硶
瓒呰嚚鐣屾祦楂旀硶鏄皣钘ョ墿銆佽仛鍚堢墿鍜岃秴鑷ㄧ晫娴侀珨婧舵恫娣峰悎鍧囧嫽鍚庯紝閫氶亷(gu貌)瑾�(di脿o)鏁存韩搴﹀拰澹撳姏浣挎暣鍊�(g猫)楂旂郴铏曚簬椋藉拰鐙�鎱�(t脿i)锛屽啀閫氶亷(gu貌)鏀硅畩婧害鍜屽鍔涚瓑锛岄檷浣庢暣鍊�(g猫)楂旂郴鐨勯＝鍜屽害锛屽緸鑰屼娇婧惰唱(zh矛)寰炴暣鍊�(g猫)楂旂郴涓瀽鍑�锛屽(sh铆)鐝�(xi脿n)鑱氬悎鐗╁皪(du矛)钘ョ墿鐨勫寘瑁�锛屽舰鎴愮矑寰戝潎涓�鐨勫井鐞�銆傝秴鑷ㄧ晫娴侀珨娌夌⿳娉曞埗鍌欏伐钘濇浠舵韩鍜�锛屽井鐞冨舰鎴愭檪(sh铆)闁撶煭銆佸寘灏佺巼楂�銆佹湁姗�(j墨)婧跺姂娈樼暀閲忓皯锛岄仼鍚堢啽鏁忔�ц棩鐗╀互鍙婃彯鐧�(f膩)鎬ц棩鐗╁井鐞冪殑鍒跺倷銆�
2.5鐔辩啍鎿犲嚭鐮旂（娉�
鐔辩啍鎿犲嚭鐮旂（娉曟槸灏囪棩鐗╁悓鑱氬悎鐗╂垨鍏朵粬杓旀枡閫�(j矛n)琛岀啍铻嶆贩鍚�锛屽緱鍒板潎鍕诲垎甯冨師鏂欒棩鐨� PLGA 姊濆鐙�鐢�(ch菐n)鍝�锛屽啀灏�(du矛)姝ょ敘(ch菐n)鍝侀��(j矛n)琛岀爺纾�锛屽緱鍒伴绮掔媭寰悆锛�鍙�氶亷(gu貌)鎺у埗鐔旇瀺婧害鍜岀爺纾ㄦ浠朵締(l谩i)瑾�(di脿o)鏁村井鐞冭棩鐗╁垎甯冪媭鎱�(t脿i)鍜岀矑寰戝ぇ灏�銆�
鐔辩啍鎿犲嚭鎶�琛�(sh霉)鍒跺倷寰悆鐨勫劒(y艒u)榛�(di菐n)锛�鈶�鍒跺倷閬�(gu貌)绋嬩腑涓嶉渶瑕佷娇鐢ㄦ湁姗�(j墨)婧跺姂锛屼笉鏈�(hu矛)甯朵締(l谩i)鏈夋(j墨)婧跺姂鐨勫晱(w猫n)椤�锛屽畨鍏ㄧ劇(w煤)姣掞紝璩�(zh矛)閲�?j墨)?y艒u)鑹�锛�鈶�鐢�(ch菐n)鐜囬珮锛岄�ｇ簩(x霉)鎬у挤(qi谩ng)锛屽寘灏佺巼鎺ヨ繎 100% 銆傜己榛�(di菐n)锛�鈶�鍒跺倷閬�(gu貌)绋嬩腑鏈夐珮婧亷(gu貌)绋�锛屽皪(du矛)婧害鏁忔劅鐨勮泲鐧藉鑲介(l猫i)钘ョ墿涓嶈兘鎳�(y墨ng)鐢ㄦ鏂规硶锛�鈶�娲绘�ц棩鐗╂垚鍒�(API)鐨勮唱(zh矛)閲忔帶鍒舵洿鍤�(y谩n)鏍硷紝闇�瑕佸湪鍒跺倷鍓嶉爯(y霉)铏曠悊锛屽叾鐩存帴褰遍熆寰悆鐨勭悊鍖栨�ц唱(zh矛)鐢氳嚦鍔熸晥銆�
2.6寰祦鎺ф妧琛�(sh霉)
寰祦鎺ф妧琛�(sh霉)鍒跺倷寰悆鐨勬柟娉曟槸閫氶亷(gu貌)寰�氶亾鐢熺敘(ch菐n)娑叉淮锛屽埄鐢ㄩ珨绌�(濡傛敞灏勫櫒娉�)鎴栧鍔�(濡傚鍔涘鍣�)鐨勯﹨(q奴)鍕�(d貌ng)鍔涘皣涓嶇浉婧剁殑閫ｇ簩(x霉)鐩稿拰鍒嗘暎鐩稿垎鍒ュ湪鍚勮嚜鐨勯�氶亾娴佸嫊(d貌ng)锛屾埃楂旀垨娑查珨鍦ㄩ�氶亾鐨勪氦鍖檿鐩搁亣锛屽埄鐢ㄩ�ｇ簩(x霉)鐩稿皪(du矛)鍒嗘暎鐩搁��(j矛n)琛屾摖澹撴垨鍓垏浣滅敤锛屼績浣跨晫闈笉绌�(w臎n)瀹氳�屾柗瑁�锛岀敓鎴愬垎鏁ｆ恫婊淬�傚井閫氶亾鍙互鍒跺倷鐨勫井鐞冨昂瀵稿湪10鍒�300μm涔嬮枔锛屽埗浣滅簿鑹殑寰�氶亾鍏�(n猫i)閮ㄧ祼(ji茅)妲�(g貌u)瑕�(gu墨)鏁达紝鑳藉淇濊瓑娑叉淮鍦ㄦ瘡涓�姊濆井閫氶亾鍏�(n猫i)鐨勫井鐠�(hu谩n)澧冨畬鍏ㄧ浉鍚�锛屽湪鎿�(ku貌)澶х敓鐢�(ch菐n)瑕�(gu墨)妯℃檪(sh铆)锛屽彧闇�瑕佸苟琛屽鍔犳暩(sh霉)閲忔垨鑰呭井鍙嶆噳(y墨ng)鍣ㄥ柈鍏�锛屾墍鏈夌殑宸ヨ棟鎺у埗鍙冩暩(sh霉)鍧囧叿鏈夊欢绾�(x霉)鎬�銆傚苟涓旈�氶亷(gu貌)涓嶅悓鍙冩暩(sh霉)杓稿叆鍒伴爯(y霉)鍏堣ō(sh猫)瑷�(j矛)鐨勬暩(sh霉)瀛�(xu茅)妯″瀷涓�锛屽氨鍙互瀵�(sh铆)鐝�(xi脿n)灏�(du矛)寰悆绮掑緫鐨勯爯(y霉)娓�(c猫)锛屽緸鑰屽揩閫熷(sh铆)鐝�(xi脿n)閲嬫斁琛岀偤鐨勫劒(y艒u)鍖栥��
寰祦鎺ф妧琛�(sh霉)鍒跺倷寰悆鐨勫劒(y艒u)榛�(di菐n)锛�鈶�鍙帶灏哄鍜屽舰鎱�(t脿i)锛氶�氶亷(gu貌)鏀硅畩娴侀�熷彲浠ユ帶鍒跺埗鍌欏井鐞冪矑寰�锛岃畩鐣扮郴鏁�(sh霉)(CV)鍙互鎺у埗鍒板皬浜� 2%銆傜敱浜庢瘡鍊�(g猫)椤嗙矑浠ョ浉鍚岀殑鏂瑰紡鍠崹(d煤)褰㈡垚锛屽彲浠ョ敓鎴愮矑寰戝潎涓�鐨勫井鐞冦��鈶�鍏锋湁鐢熺敘(ch菐n)澶氫钩鍔戠殑鑳藉姏锛屽湪鍚勭浉閫氶亾鍏�(n猫i)閫氬叆澶氱浉浜掍笉鐩告憾鐨勬憾娑蹭娇鍏跺湪寰�氶亾鍏�(n猫i)渚濇鍓垏骞朵钩鍖�锛屼竴灞や竴灞ゅ寘瑕嗗緸鑰屽舰鎴愬垎鏁ｇ殑澶氶噸涔虫恫锛�鈶�鍦ㄦ斁澶ч亷(gu貌)绋嬩腑鍏锋湁楂樺害鐨勯噸鐝�(xi脿n)鎬�銆傚ぇ瑕�(gu墨)妯″苟琛屽寲鍙互澶ф壒閲忕敓鐢�(ch菐n)锛屽悓鏅�(sh铆)淇濇寔鍥哄畾鐨勭敘(ch菐n)鍝佺壒鎬�锛�鈶�涔冲寲銆佽仛鍚堝拰鍒嗘瀽鐨勯亷(gu貌)绋嬪鏄撶祼(ji茅)鍚�锛�鈶�绯荤当(t菕ng)鏄皝闁夌殑锛屽洜姝ゅ彲浠ユ秷闄ょ┖姘�/姘ф埃灏�(du矛)钘ョ墿鐨勯檷瑙�锛屽悓鏅�(sh铆)瀹规槗閫�(j矛n)琛岀劇(w煤)鑿岀敓鐢�(ch菐n)銆傜己榛�(di菐n)锛�鈶�娓呮礂姣旇純鍥伴洠锛�鈶�鐢熺敘(ch菐n)鏁堢巼閭勬湁寰呮彁楂�锛屼互婊�(m菐n)瓒冲伐妤�(y猫)鍖栫敓鐢�(ch菐n)锛�鈶�闋�(y霉)娓�(c猫)娑叉淮鐩村緫鐨勬ā鍨嬭純灏戙��
2.7 SPG鑶滀钩鍖栨硶
鏍规摎(j霉)鑶滀钩鍖栧埗鍌欓亷(gu貌)绋嬬殑鎴愪钩鍘熺悊锛岃啘涔冲寲鎶�琛�(sh霉)涓昏鍙垎鐐哄叐澶ч(l猫i)鍨嬶細鐩存帴(甯歌(gu墨)) 鑶滀钩鍖栧拰蹇�熻啘涔冲寲锛屽叐绋啘涔冲寲鏂规硶鍦ㄥ埗鍌欑矑寰戝潎涓�鐨勪钩娑茬殑閬�(gu貌)绋嬪悇鏈夊劒(y艒u)鍕�(sh矛)锛岄仼鐢ㄧ殑涔�娑�绮掑緫鎺у埗鑼冨湇涓嶅悓銆�鐩存帴涔冲寲鏄皣鍒嗘暎鐩稿拰閫ｇ簩(x霉)鐩稿垎鍒ユ簴(zh菙n)鍌欏湪涓嶅悓鐨勫鍣ㄤ腑锛屽垎鏁ｇ浉绌块亷(gu貌)SPG鑶滃埄鐢ㄨ〃闈㈠嫉鍔涚敘(ch菐n)鐢熷潎鍕荤殑涔冲寲娑�锛岄�ｇ簩(x霉)鐩歌姹傝紩寰殑娴佸嫊(d貌ng)锛屼钩鍖栨恫鐨勭矑瀛愬ぇ灏忔槸3-4鍊嶇殑SPG鑶滅殑瀛斿緫锛�蹇�熻啘涔冲寲鍣ㄧ殑宸ヤ綔鍘熺悊鏄�氶亷(gu貌)灏囧父瑕�(gu墨)涔冲寲娉曞埗鍌欑矑寰戝ぇ浜庤啘瀛斿瓟寰戠殑闋�(y霉)涔虫恫锛岄毃鍚庡埄鐢ㄥ閮ㄥ鍔涘皣闋�(y霉)涔虫恫蹇�熼�氶亷(gu貌)灏哄澶у皬鍙伕鎿囩殑寰瓟鑶�锛屽舰鎴愮矑寰戝潎涓�鐨勪钩婊�锛�涓�鑸噸寰�(f霉)鎿嶄綔3-5娆″悗锛屽嵆鍙緱鍒扮矑寰戝潎涓�鐨勪钩娑诧紝涔冲寲娑茬殑绮掑瓙澶у皬涓�鑸皬浜�SPG鑶滅殑瀛斿緫锛汼PG鑶�涔虫恫鍥哄寲鍚庡嵆鍙緱鍒扮矑寰戝潎涓�鍙帶鐨勮級钘ュ井鐞�銆�
鑶滀钩鍖栨妧琛�(sh霉)鍒跺倷寰悆鐨勫劒(y艒u)榛�(di菐n)锛�鈶�寰悆灏哄鍧囦竴鍙帶锛屽井鐞冪矑寰戝彇姹轰簬鑶滃瓟寰戯紝寰悆鍒跺姂鎵规闁撻噸寰�(f霉)鎬уソ锛�鈶�鍙嶆噳(y墨ng)姊濅欢婧拰锛屽彲浠ョ敤浜庡皪(du矛)鏀媽鏁忔劅鐨勮泲鐧藉鑲介(l猫i)钘ョ墿锛�鈶�涔虫恫绌�(w臎n)瀹氭�уソ锛屽埗鍌欓亷(gu貌)绋嬩腑鍒╃敤琛ㄩ潰娲绘�у姂涓嶆槗鐧�(f膩)鐢熶钩娑�鍦�(tu谩n)鑱�銆佺牬涔�鐝�(xi脿n)璞�锛�琛ㄩ潰娲绘��鍔戠敤閲忓皯锛�鈶�鎿嶄綔閬�(gu貌)绋嬬啊(ji菐n)渚�锛屾槗浜庡伐妤�(y猫)瑕�(gu墨)妯℃摯(ku貌)澶х敓鐢�(ch菐n)銆傜己榛�(di菐n)锛�鈶�鍒跺倷鐨勫井鐞冪矑寰戦亷(gu貌)浜庡柈涓�锛屾渻(hu矛)褰遍熆钘ョ墿楂斿収(n猫i)閲嬫斁鍛ㄦ湡锛屽苟涓旀湁閫犳垚绐佺劧閲嬫斁鐨勫嵄闅�(xi菐n)锛屾湁寰呴��(j矛n)涓�姝ョ爺绌�锛�鈶�鐩墠閭勬矑(m茅i)鏈夋噳(y墨ng)鐢ㄨ啘涔冲寲鎶�琛�(sh霉)鐢熺敘(ch菐n)鐨勫井鐞冪敘(ch菐n)鍝佷笂甯�锛屼富瑕佸埗绱勫洜绱犲湪浜庣敓鐢�(ch菐n)瑷�(sh猫)鍌欎腑鑶滄潗璩�(zh矛)瑕佺鍚堝閲嶈姹傦細姗�(j墨)姊板挤(qi谩ng)搴﹀挤(qi谩ng)銆佷繚鎸佸瓟寰戝ぇ灏忎繚鎸佺┅(w臎n)瀹�銆佹槗浜庢竻娲�锛屼笉鏄撳牭濉�銆�
鍒跺倷鐨勫伐钘濆拰瑷�(sh猫)鍌欙細鏃ユ湰SPG鍏徃鐧�(f膩)鏄庣殑鑶滀钩鍖栨妧琛�(sh霉)鏄檪(sh铆)闁撲笂鍞竴鑳藉埗鍌欏潎涓�寰悆鐨勬柟娉曪紝骞朵笖鑳介伕鎿囦笉鍚屽瓟寰戠殑鑶�锛屼締(l谩i)鐛插緱涓嶅悓澶у皬鐨勫井鐞�锛屽皪(du矛)鎳�(y墨ng)鐨勮ō(sh猫)鍌欏緸寰噺妯ｅ搧鍒板ぇ瑕�(gu墨)妯＄敓鐢�(ch菐n)锛屽叾涓�MG-20鍜�KH-125鏄渶甯哥敤鐨勫瀷铏�(h脿o)銆�
2.8 楂樺鍧囪唱(zh矛)鏂规硶
鐐轰簡瀵�(sh铆)鐝�(xi脿n)鍦ㄦ恫楂斾腑闀�(zh菐ng)鏈熸贩鍚堜竴绋垨澶氱ó鐗╄唱(zh矛)锛岄珮澹撳潎璩�(zh矛)姗�(j墨)鑳�灏�娑查珨涓垎鏁ｇ殑鎳告诞鐗╄唱(zh矛)寰�?锛�?锛屾ǎ鍝佸湪浣庨�熷拰楂樺鐨勬儏娉佷笅鍒伴仈(d谩)鍧囪唱(zh矛)闁ラ杸(m茅n)鏅�(sh铆)锛屽湪鍚勭ó鍔涚殑浣滅敤涓嬭�屼娇妯ｅ搧寰�?锛涱嚇绨ゆ桅鑶楄p灏忚�屽紩璧烽湩鍖栫殑姘寸彔涔嬮枔鎽╂摝銆侀珮闋绘摼鍕�(d貌ng)锛屾渶鍚庝互妤甸珮鐨勯�熷害娌栨搳鍒扮鎾炵挵(hu谩n)涓�锛岃�岀敘(ch菐n)鐢熸挒鎿�锛屽叾閬�(gu貌)绋嬪寘鍚簡绌�绌�鏁堟噳(y墨ng)銆佺鎾炴晥鎳�(y墨ng)鍜屽壀鍒囨晥鎳�(y墨ng)绛�锛岄仈(d谩)鍒扮窗(x矛)鍖栧拰鍧囪唱(zh矛)鐨勪綔鐢�锛岀嵅寰楄秴绱�(x矛)鐨勫井鐞冨拰娑叉淮銆傞珮澹撳潎璩�(zh矛)姗�(j墨)鍙互浣跨敤鍠礆(j铆)鍧囪唱(zh矛)闁ラ杸(m茅n)锛岄仼浜庡柈绱旂殑鍒嗘暎闋�(y霉)铏曠悊锛涗篃鍙互浣跨敤鍏╃礆(j铆)鍧囪唱(zh矛)闁ラ杸(m茅n)锛岄仼浜庝钩鍖栨恫妯ｅ搧鍜屽皪(du矛)绮樺害鏈夎姹傜殑妯ｅ搧銆�
楂樺鍧囪唱(zh矛)姗�(j墨)甯哥敤浜庡埗鍌欏井绫崇磵绫充钩鍔�銆佸井绮掋�佽剛璩�(zh矛)楂�锛屼竴鑸槸鍏堝埄鐢ㄦ敧鎷屽壀鍒囬��(j矛n)琛屽垵涔冲埗鍌欙紝鍐嶇稉(j墨ng)閬�(gu貌)楂樺鍧囪唱(zh矛)寰楀埌杓冨皬绮掑緫鐨勫埗鍔�锛屽叾绮掑緫澶у皬涓�鑸渻(hu矛)鍛堟鎱�(t脿i)鍒嗗竷锛岄珮澹撳潎璩�(zh矛)姗�(j墨)鐨勫彲鎺у弮鏁�(sh霉)鏈夊潎璩�(zh矛)澹撳姏銆佸惊鐠�(hu谩n)娆℃暩(sh霉)(寰挵(hu谩n)鏅�(sh铆)闁�)鍜屾韩搴︾瓑锛屽井绮掑ぇ灏忓拰鍒嗗竷涓�鑸毃钁楀潎璩�(zh矛)澹撳姏澧炲姞鍜屽惊鐠�(hu谩n)娆℃暩(sh霉)澧炲鏄庨’涓嬮檷锛岄仈(d谩)鍒颁竴瀹氬鍔涘拰寰挵(hu谩n)娆℃暩(sh霉)鍚庢几瓒ㄥ钩琛�锛屼篃鏈夌殑涔虫恫鐣�(d膩ng)鍧囪唱(zh矛)澹撳姏鍜屽惊鐠�(hu谩n)娆℃暩(sh霉)瓒呴亷(gu貌)涓�瀹氬�煎悗锛岀矑寰戝拰鍒嗗竷鍙嶈�屽鍔狅紝鍥犺�屽瓨鍦ㄤ竴鍊�(g猫)鏈�浣崇殑瀵�(sh铆)椹�(y脿n)鍙冩暩(sh霉)銆�
鍒跺倷鐨勫伐钘濆拰瑷�(sh猫)鍌欙細鎰忓ぇ鍒�FBF鍏徃涓�鐩磋嚧鍔涗簬楂樺鍧囪唱(zh矛)姗�(j墨)鐨勭爺鐧�(f膩)鍜岀敓鐢�(ch菐n)锛屽叾瀵�(sh铆)椹�(y脿n)瀹ゅ瀷铏�(h脿o)HomoLab鐨勬渶楂樺潎璩�(zh矛)澹撳姏鍙互閬�(d谩)鍒�1800bar锛岃檿鐞嗚兘鍔涚偤20L/灏忔檪(sh铆)锛屾渶灏忚檿鐞嗛噺鐐�50ml鐨勬ǎ鍝侊紝鐛�(d煤)鏈夌殑寮�(qi谩ng)鍒堕��(j矛n)妯ｆ妧琛�(sh霉)鐗瑰垾閬╁悎楂樼矘搴︽ǎ鍝佺殑鍧囪唱(zh矛)鍜屽埗鍌欑壒娈婄殑寰悆锛涗腑瑭﹀拰鐢熺敘(ch菐n)鍨嬭櫉(h脿o)鏈夎繎鐧剧ó渚涢伕鎿�锛屼互婊�(m菐n)瓒充笉鍚岀敤鎴�(h霉)涓嶅悓鐨勬噳(y墨ng)鐢ㄩ渶姹傘��
3.寰悆鍒跺姂鐢�(ch菐n)鍝佺殑璩�(zh矛)閲忔帶鍒�
閫氬父瑭�(p铆ng)鍍�(ji脿)寰悆鐨勬寚妯�(bi膩o)鏈夊井鐞冨舰鎱�(t脿i)銆佺矑寰戝強鍏跺垎甯�銆佽級钘ラ噺銆佸寘灏佺巼鍙婂叾閲嬫斁搴�锛屾湁鏅�(sh铆)閭勫寘鎷湁闂�(gu膩n)鐗╄唱(zh矛)鍜屾憾鍔戞畼鐣欑瓑闋�(xi脿ng)鐩��
3.1褰㈡厠(t脿i)
閫氶亷(gu貌)鎺冩弿闆诲瓙椤井閺℃垨鑰呴�忓皠闆诲瓙椤井閺¤瀵熷井鐞冪殑褰㈡厠(t脿i)锛屽褰㈢媭(鍦撳舰鎴栭(l猫i)鍦撳舰)銆佽〃闈㈠舰璨�(鍏夋粦鎴栫矖绯�)銆侀鏋剁祼(ji茅)妲�(g貌u)(澶氬瓟鎴�?q奴)宓�?/font>)銆傚井鐞冨舰鎱�(t脿i)鑸囩祼(ji茅)妲�(g貌u)鐨勪笉鍚屽皪(du矛)寰悆鐨勮級钘ラ噺浠ュ強閲嬫斁琛岀偤鏈夐’钁楀奖闊�銆傝〃闈㈢矖绯欑殑寰悆鏄撳惛闄勮棩鐗╃祼(ji茅)鏅讹紝寰�寰�鏈�(hu矛)灏�(d菐o)鑷撮珮绐侀噵銆傞�氶亷(gu貌)灏�(du矛)寰悆褰㈡厠(t脿i)閫�(j矛n)琛岃娓�(c猫)锛岀附绲�(ji茅)褰㈡厠(t脿i)鑸囪檿鏂瑰伐钘濅箣闁撶殑闂�(gu膩n)绯伙紝涓嶄絾鍙互灏�(du矛)寰悆鐨勫埗鍌欐(j墨)鐞嗛��(j矛n)琛屾帰绱�锛岄倓鍙互灏�(du矛)閲嬫斁琛岀偤閫�(j矛n)琛屽劒(y艒u)鍖�銆�
3.2绮掑緫鍙婂垎甯�
褰遍熆寰悆鐢�(ch菐n)鍝侀噵鏀惧害鐨勯棞(gu膩n)閸靛洜绱犱富瑕佹槸绮掑緫鍜岀矑寰戠殑鍒嗗竷銆傜矑寰戞脯(c猫)瀹氭柟娉曟湁寰堝绋�锛屼富瑕佸寘鎷嫊(d貌ng)鎱�(t脿i)鍏夋暎灏勬硶锛�DLS锛�銆佹縺鍏夎灏勬硶锛�LLD锛�銆侀�忓皠闆婚彙锛�TEM锛�浠ュ強鎺冩弿闆婚彙锛�SEM锛�銆佸師瀛愬姏瀛�(xu茅)椤井閺★紙AFM锛夌瓑銆傚叾娓�(c猫)閲忔柟娉曞悇鏈夊劒(y艒u)缂洪粸(di菐n)锛�DLS 娉曞彲婧�(zh菙n)纰烘脯(c猫)閲忕殑绮掑緫鑼冨湇杓冪獎锛�LLD 娉曟脯(c猫)閲忕矑寰戣寖鍦嶇偤1锝�1000μm锛屼絾鍏堕渶瑕佺殑妯ｅ搧閲忓ぇ锛岃��TEM銆�SEM鏄撳彈妯ｅ搧鍒跺倷閬�(gu貌)绋嬪奖闊�锛�AFM 鍓囪ō(sh猫)鍌欒純寰�(f霉)闆�锛�缍滀笂鎵�杩�锛屾縺鍏夎灏勬硶浠嶆槸鏈�甯哥敤鐨勬脯(c猫)閲忕矑寰戝強绮掑緫鍒嗗竷鐨勬柟娉�銆�
3.3杓夎棩閲�/鍖呭皝鐜�
杓夎棩閲忔槸鎸囧井鐞冨埗鍔戜腑鎵�鍚棩鐗╃殑璩�(zh矛)閲忓垎?j菒n)?sh霉)锛岃�屽寘灏佺巼鏄寚寰悆鍒跺姂涓寘灏佺殑钘ラ噺鍗犲井鐞冨埗鍔戜腑鍖呭皝鑸囨湭鍖呭皝绺借棩閲忕殑姣斿�硷紝浜岃�呮槸琛￠噺鍒跺倷宸ヨ棟鍜屾垚鏈殑閲嶈鎸囨(bi膩o)銆傚叾妾㈡脯(c猫)鏂规硶涓�鑸槸鍏堥噰鐢ㄥ悎閬╃殑鏈夋(j墨)婧跺姂灏囧井鐞冮珮鍒嗗瓙鏉愭枡楠ㄦ灦婧惰В锛屽啀鏍规摎(j霉)钘ョ墿鐨勬�ц唱(zh矛)閬告搰涓嶅悓鐨勬柟娉曞皣钘ョ墿鍒嗛洟鎴栨彁鍙栧嚭渚�(l谩i)锛岄��(j矛n)琛屽惈閲忔脯(c猫)瀹�銆�
3.4閲嬫斁搴�
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3.5楂樺垎瀛愯仛鍚堢墿鐨勭幓鐠冨寲杞�(zhu菐n)璁婃韩搴﹁垏鏅跺瀷鏀硅畩
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